Aerobic exercise can reduce the risk of metastatic cancer by 72 percent, according to a new study. According to the researchers, during vigorous aerobic exercise, the amount of glucose (sugar) absorbed by internal organs increases, decreasing the amount of energy cancer can access. Professor Carmit Levy from the Department of Human Genetics and Biochemistry and Dr Yftach Gepner from the School of Public Health and Sylvan Adams Sports Institute at TAU’s Sackler Faculty of Medicine led the research. prof. Levy notes that the new study made an important discovery that could help prevent metastatic cancer, the leading cause of death in Israel, by pooling scientific expertise from many of TAU’s schools. The article was accepted for publication in the esteemed journal Cancer Research and the cover was selected for the November 2022 issue. The study combined an animal model in which mice were trained under a strict exercise regimen, with data from healthy human volunteers who exercised before and after running. were investigated. The human data, obtained from an epidemiological study that followed 3,000 individuals for about 20 years, indicated a 72 percent reduction in metastatic cancer among participants who reported regular, high-intensity aerobic activity, compared with those who did not exercise. The animal model showed a similar result, which also allowed the researchers to identify the underlying mechanism. When sampling the internal organs of the physically fit animals, before and after exercise, and also after cancer injection, they found that aerobic activity significantly reduced the development of metastatic tumors in the lymph nodes, lungs and liver. The researchers hypothesized that this beneficial outcome in both humans and model animals is related to the increased glucose consumption caused by exercise.