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Green tea extract may be harmful to the liver in patients with certain genetic variations News

December 2, 2022, 5:30 PM ISTSource: ANI

According to one study, long-term use of high-dose green tea extract may provide some protection against cancer, cardiovascular disease, obesity and type 2 diabetes, but it may also cause liver damage in a small number of people. The research team investigated whether people with certain genetic variations were more likely than others to show signs of liver stress after a year of consuming 843 milligrams per day of the predominant antioxidant in green tea, a catechin called epigallocatechin gallate (EGCG). An analysis by researchers showed that early signs of liver injury were slightly more common than normal in women with one variation in the Catechol-O-methyltransferase (COMT) genotype and strongly predicted by a variation in the uridine 5′-diphospho-glucuronosyltransferase 1A4 (UGT1A4 ) genotype. On average, participants with the high-risk UGT1A4 genotype saw the enzyme that signals liver stress rise nearly 80 percent after taking the green tea supplement for nine months, while those with low-risk genotypes saw the same enzyme rise by 30 percent.



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